Research Associate I

Research Associate I

Location: Lexington, MA
Details: On-site, 5 days/week (in Lab)

Job Description: Join our multinational and diverse team as a Research Associate in the Nucleic Acid Delivery, Formulations & Bioanalysis department. Collaborating with Laboratory Technicians, Specialists/Scientists, and a global department manager, you will contribute to the development of synthetic/non-viral nanomedicines, employing advanced analytical characterization techniques, and facilitating the transition to preclinical and clinical studies through internal and external collaborations.

Essential Functions:

• Regularly formulate and characterize lipid nanoparticles (LNPs) loaded with nucleic acids at small to mid-scale using microfluidics, ensuring reproducibility and scalability while maintaining high product quality and consistency.
• Conduct freeze-drying studies to evaluate the stability of LNP formulations, including assessing critical formulation parameters and optimizing freeze-drying cycles for maximum stability and efficacy.
• Communicate findings to the team through presentations and written reports.
• Independently plan, execute, and document experiments.

Qualifications:

• Bachelor's degree strongly preferred with a minimum of 2 years relevant experience required, OR high school diploma with 8+ years relevant experience, OR Associate or Vocational degree with 4+ years relevant experience may also be considered.
• Relevant experience can include a combination of industry and academic settings and should encompass some of the following:
• Hands-on experience in formulating lipid nanoparticles at small to mid-scale using microfluidics.
• Experience with analytical methods, including biophysical techniques like dynamic light scattering (DLS) and fluorescent-based assays (e.g., Ribogreen/PicoGreen), chromatography, and pH measurements.
• Hands-on experience in lyophilization of lipid nanoparticles.
• Proficiency in maintaining good lab practices and adhering to equipment SOPs.
• Experience with automation is a plus.

Top 3 Must-Have Skills:

1. Hands-on experience in formulating lipid nanoparticles at small to mid-scale using microfluidics.
2. Hands-on experience in characterizing lipid nanoparticles loaded with nucleic acids (e.g., Ribogreen, DLS).
3. Hands-on experience in lyophilization of lipid nanoparticles.

About Advanced Clinical

Advanced Clinical is an award-winning clinical development organization that provides global services including CRO, Functional Support, Quality & Validation, Patient Recruitment and Retention, and Strategic Talent Acquisition solutions for pharmaceutical, biopharmaceutical, biotechnology, and medical device organizations. Our mission is to deliver a truly better clinical experience for our clients and candidates. To learn more about Advanced Clinical which has been named to Chicago Tribune's Top Workplaces, Chicago's Best and Brightest Companies, and Best of Staffing Talent & Client, visit http://www.advancedclinical.com.

Regarding your application

Please know that every completed application is carefully reviewed by the Advanced Clinical recruitment team. We understand the time commitment that is needed to prepare an application, so we respect your effort by thoughtfully reviewing and responding to each application. In return, we ask for your patience as careful review takes time, and we may not be able to respond to every application immediately.

It is Advanced Group's practice not to discriminate against any employee or applicant because of sex, race, color, age, national origin, religion, gender, gender identity/expression, sexual orientation/sexual preference, pregnancy/maternity, genetic information, marital status, physical/mental disability, medical condition, military/veteran status, or any other basis protected by applicable federal, state, or local law. If you have a disability or handicap and would like us to accommodate you in any reasonable way, please inform your recruiter so that we can discuss the appropriate alternatives available.

Job ID#511149