Research Assistant I- Yu Lab

Yu lab now focuses on autism genetics and translational genomics. Dr. Timothy Yu is a PI in the Division of Genetics and Genomics at Boston Children's Hospital and an Associate Member of the Broad Institute of MIT and Harvard. Current projects range from computational genomic analyses of large autism cohorts to identify disease genes, to investigations of genome sequencing for newborn screening and neonatal ICU care, to the development of platform approaches for individualized therapy of rare neurogenetic diseases. We work collaboratively to analyze gene knockouts in a large-scale collection of whole exome and genome data from over 40,000 individuals with autism, gathered by the Simons Foundation and the Autism Sequencing Consortium. We are also creating new models for the delivery of translational genomic medicine: accelerating diagnosis and treatment with rapid-turnaround genomic sequencing in the neonatal intensive care unit, applying genome sequencing in the newborn nursery to supplement traditional screening, and creating institution-wide rare disease genomics cohorts to accelerate discovery. We are also pioneering disruptive approaches to individualized genomic medicine using antisense oligonucleotides (ASOs). We were responsible for creating the world's first fully individualized medicine in 2018, using a patient-customized ASO to treat a young girl with fatal neurogenetic disease. We now have additional n=1 therapies in preclinical or clinical stages, and are working closely with the FDA to solidify this path for more patients.

Our lab works at the intersection of genetics, neurobiology, and bioinformatics to understand the basis for rare pediatric neurologic disease and advance genomic medicine. This role would be a perfect fit for someone looking to expand their skillset and knowledge before moving on to graduate school or their next adventure.

This Research Assistant I will be responsible for:

• Assisting in basic science and translational research projects under the supervision of the project head and the lab manager.
• These duties include performing laboratory experiments, collection and accurate recording of procedures and results, ordering necessary reagents to conduct experiments and participation in joint upkeep of the lab.
• Assist lab staff with research experiments in human genetics and genomics
• Using and understanding a wide variety of molecular biology protocols - such as extracting DNA, RNA, and proteins from cultured cell lines, blood and tissue samples
• Culturing both primary cells and cell lines
• Maintain required equipment
• Participate in laboratory meetings and read literature applicable to the research area
• Help with lab organization and other support duties relating to lab operations, as required

In order to qualify, you must have:

• Bachelor's Degree in biology, biochemistry, neuroscience, genomics or related fields.
• 6+ months of prior experience working in a research laboratory highly preferred.
• Research experience as a technician or conducting independent research project preferred.
• Excellent analytical, communication, problem solving, and organizational skills
• Ability to work both independently and as a team member
• Able to learn complex tasks with general instruction, and to use experience to perform a variety of new techniques
• Actively seeks opportunities to increase skills and expertise
• Experience with tissue culture or animal handling (mice/vertebrates) a plus
• Must be self-motivated and reliable.
• Attention to detail in experimental techniques and record keeping
• Proficiency in Word, PowerPoint, Excel, and Internet searches.

Boston Children's Hospital offers unmatched benefits including flexible schedules, affordable health, vision and dental insurance, student loan subsidies, generous levels of time off, Tuition Reimbursement and discounted rates on T-passes. Experience the benefits of passion and teamwork.