Scientist, Biology

The Research Department at Alnylam is seeking a scientist to contribute to our targeted delivery efforts for expanding RNAi into new tissues. The candidate will contribute to platform efforts centered on extrahepatic siRNA delivery and work closely with RNAi Platform, Medicinal Chemistry, and Delivery Sciences teams. This position will focus on developing tools and screening compounds to characterize delivery strategies for RNAi therapeutics. This lab-based position will be onsite at our Cambridge location.

Key Responsibilities

• Design plasmid contructs for generating cell lines stably expressing membrane proteins
• Organize and maintain a functional inventory of plasmid sequences
• Establish tools, execute assays, and develop in vitro models to evaluate delivery and activity of siRNA conjugates
• Work collaboratively across the organization to optimize RNA drugs for tissue-specific delivery
• Design controlled experiments, analyze data, and present findings to various groups across the research organization

Qualifications

• PhD in biochemistry, molecular biology, or a related field with up to 3 years of work experience in an industry setting
• Experience in the design and optimization of plasmids for efficient cellular expression of membrane proteins is required
• Expertise with mammalian cell culture including general maintenance, transfection and transduction, imaging techniques, and cell line generation is required
• Experience with standard biochemical and cell-based assays for assessing receptor/ligand interactions (flow cytometry, microscopy, ELISA, BLI) is strongly preferred
• Experience with plasmid registration and inventory maintenance is preferred
• Strong interpersonal skills and excellent communication skills (written and oral) are required

• #LI-JR1

U.S. Pay Range

$111,400.00 - $157,000.00

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers

AboutAlnylam

We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.